Abstracts: Genotoxic Effects of MSG
Recent Abstracts: Genotoxic Effects of MSG
[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||6px|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Investigating DNA Damage Mechanism Induced by Monosodium Glutamate and Associated DNA Repair Cell Machinery: A Literature Review” image=”https://www.immortalme.com/wp-content/uploads/2025/01/Screenshot-2025-01-21-143417.png” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h2″ header_text_color=”#000000″ header_font_size=”23px” body_text_color=”#000000″ body_font_size=”17px” custom_padding=”8px|10px|8px|10px|false|false” border_radii=”on|6px|6px|6px|6px” border_color_all=”#84776C” box_shadow_style=”preset1″ box_shadow_spread=”8px” box_shadow_color=”#84776C” global_colors_info=”{}”]
Aghaei et al. (2021) explores the damaging effects of Monosodium Glutamate on DNA and the body’s endogenous pathways for DNA repair. The review emphasizes that with the increasing use of food additives like MSG, the risk of DNA damage is becoming more prominent. It discusses the genotoxicity of MSG, methods to detect and repair DNA damage, and natural compounds that may help prevent such damage. This comprehensive overview provides a foundational understanding of how MSG can affect genetic material.
[/et_pb_blurb][et_pb_button button_url=”https://doi.org/10.26685/urncst.279″ button_text=”Full Article” button_alignment=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”17px” button_text_color=”#84776C” button_bg_color=”#F2F2F2″ button_border_width=”2px” button_border_color=”#84776C” button_border_radius=”6px” custom_margin=”2px||||false|false” custom_padding=”1px|||||” box_shadow_style=”preset1″ box_shadow_spread=”3px” box_shadow_color=”#84776C” global_colors_info=”{}”][/et_pb_button][/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Neuroprotective Potential of Allium Sativum Against Monosodium Glutamate-Induced Excitotoxicity. Impact of Short-Term Memory, Gliosis, and Oxidative Stress” image=”https://www.immortalme.com/wp-content/uploads/2025/01/Screenshot-2025-01-21-174018.png” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h2″ header_text_color=”#000000″ header_font_size=”23px” body_text_color=”#000000″ body_font_size=”17px” custom_padding=”8px|10px|8px|10px|false|false” border_radii=”on|6px|6px|6px|6px” border_color_all=”#84776C” box_shadow_style=”preset1″ box_shadow_spread=”8px” box_shadow_color=”#84776C” global_colors_info=”{}”]Hazzaa et al. (2020) further elucidate the mechanisms of MSG-induced damage. Their study indicates that the activation of glutamate receptors leads to the release of calcium ions, which subsequently activates intracellular enzymes such as endonucleases and phospholipases. These enzymes can damage various cellular structures, including DNA. The study also notes that MSG treatment in rats resulted in cognitive deficits and hippocampal degeneration, suggesting a broader impact on brain function and cellular integrity.
[/et_pb_blurb][et_pb_button button_url=”https:doi.org/10.3390/nu12041028″ button_text=”Full Article” button_alignment=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”17px” button_text_color=”#84776C” button_bg_color=”#F2F2F2″ button_border_color=”#84776C” button_border_radius=”6px” custom_margin=”2px||||false|false” custom_padding=”1px|||||” box_shadow_style=”preset1″ box_shadow_spread=”3px” box_shadow_color=”#84776C” global_colors_info=”{}”][/et_pb_button][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#F2F2F2″ custom_margin=”0px||0px||false|false” custom_padding=”31px||7px||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||6px|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Monosodium Glutamate-Induced Oxidative Damage and Genotoxicity in the Rat: Modulatory Role of Vitamin C, Vitamin E, and Quercetin” image=”https://www.immortalme.com/wp-content/uploads/2025/01/Screenshot-2025-01-21-141202-1.png” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h2″ header_text_color=”#000000″ header_font_size=”23px” body_text_color=”#000000″ body_font_size=”17px” custom_padding=”8px|10px|8px|10px|false|false” border_radii=”on|6px|6px|6px|6px” border_color_all=”#84776C” box_shadow_style=”preset1″ box_shadow_spread=”8px” box_shadow_color=”#84776C” global_colors_info=”{}”]Farombi & Onyema (2006) also reported on the oxidative damage and genotoxicity induced by Monosodium Glutamate in rats. Their study found that MSG administration led to increased levels of reactive oxygen species (ROS), which are known to cause oxidative stress and subsequent DNA damage. The study suggested that antioxidants like vitamins C and E could mitigate the genotoxic effects of MSG, emphasizing the role of oxidative stress in MSG-induced DNA damage.
[/et_pb_blurb][et_pb_button button_url=”https:doi:10.1191/0960327106ht621oa” button_text=”Full Article” button_alignment=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”17px” button_text_color=”#84776C” button_bg_color=”#F2F2F2″ button_border_color=”#84776C” button_border_radius=”6px” box_shadow_style=”preset1″ box_shadow_spread=”3px” box_shadow_color=”#84776C” global_colors_info=”{}”][/et_pb_button][/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Roles of Moringa Oleifera Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats” image=”https://www.immortalme.com/wp-content/uploads/2025/01/Screenshot-2025-01-21-135038.png” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h2″ header_text_color=”#000000″ header_font_size=”23px” body_text_color=”#000000″ body_font_size=”17px” custom_padding=”8px|8px|8px|8px|false|false” box_shadow_style=”preset1″ box_shadow_spread=”8px” box_shadow_color=”#84776C” global_colors_info=”{}”]Albrahim and Binobead (2018) quantitatively assessed the genotoxicity of MSG, demonstrating its strong ability to cause DNA damage. Their findings revealed that MSG significantly increased DNA damage in hepatocytes, and the administration of Moringa leaf extract reduced this damage, indicating a potential protective effect against MSG-induced genotoxicity. This study underscores the direct relationship between MSG consumption and DNA integrity.
[/et_pb_blurb][et_pb_button button_url=”https://doi.org/10.1155/2018/4501097″ button_text=”Full Article” button_alignment=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”17px” button_text_color=”#84776C” button_bg_color=”#F2F2F2″ button_border_color=”#84776C” button_border_radius=”6px” custom_margin=”2px||||false|false” box_shadow_style=”preset1″ box_shadow_spread=”3px” box_shadow_color=”#84776C” global_colors_info=”{}”][/et_pb_button][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#F2F2F2″ custom_margin=”0px||0px||false|false” custom_padding=”31px||7px||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||6px|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Assessment of Genotoxic Effects of Some Food Additives on Some Human Cancer Cells” image=”https://www.immortalme.com/wp-content/uploads/2025/01/Screenshot-2025-01-21-153407.png” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h2″ header_text_color=”#000000″ header_font_size=”23px” body_text_color=”#000000″ body_font_size=”17px” custom_padding=”10px|10px|10px|12px|false|false” border_radii=”on|6px|6px|6px|6px” border_color_all=”#84776C” box_shadow_style=”preset1″ box_shadow_spread=”8px” box_shadow_color=”#84776C” global_colors_info=”{}”]Rashad et al. (2019) conducted research that confirmed Monosodium Glutamate’s genotoxic effects on human peripheral blood lymphocytes. Their findings indicated that MSG inflicted DNA damage at all concentrations tested, further supporting the notion that MSG is genotoxic and poses risks to human health. This study is particularly relevant as it highlights the effects of MSG on human cells, providing a direct link to potential health implications.
[/et_pb_blurb][et_pb_button _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][/et_pb_button][et_pb_button button_url=”https:doi:%2010.21608/ajs.2019.43668″ button_text=”Full Article” button_alignment=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”17px” button_text_color=”#84776C” button_bg_color=”#F2F2F2″ button_border_color=”#84776C” button_border_radius=”6px” custom_margin=”2px||||false|false” box_shadow_style=”preset1″ box_shadow_spread=”3px” box_shadow_color=”#84776C” global_colors_info=”{}”][/et_pb_button][/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#F2F2F2″ custom_margin=”0px||-2px||false|false” custom_padding=”31px||2px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” min_height=”115.2px” custom_margin=”-15px|auto||auto||” custom_padding=”6px||9px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”||||||||” text_text_color=”#000000″ text_font_size=”17px” global_colors_info=”{}”]In summary, a growing body of evidence supports the assertion that monosodium glutamate can induce DNA damage through various mechanisms, including oxidative stress and the activation of damaging intracellular pathways. Studies have shown that MSG’s genotoxic effects extend to both animal models and human cells, raising concerns about its safety as a food additive. Continued research is essential to fully understand the implications of MSG consumption on genetic integrity and overall health.
[/et_pb_text][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#F2F2F2″ custom_padding=”0px||54px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#84776C” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||29px|||” global_colors_info=”{}”][/et_pb_divider][et_pb_toggle title=”References” open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#84776C” toggle_icon=”||fa||900″ use_icon_font_size=”on” icon_font_size=”25px” open_icon_color=”#E02B20″ open_toggle_icon=”||fa||900″ open_use_icon_font_size=”on” open_icon_font_size=”25px” _builder_version=”4.27.4″ _module_preset=”default” title_text_color=”#000000″ title_font=”Cormorant Garamond||||||||” title_text_align=”left” title_font_size=”20px” text_orientation=”left” custom_margin=”||0px|||” custom_padding=”|||20px|false|false” border_radii=”on|6px|6px|6px|6px” box_shadow_style=”preset1″ box_shadow_color=”#84776C” global_colors_info=”{}”]1. Aghaei, Novin, Teodora Grigorescu, Nia Katani. “Investigating dna damage mechanism induced by monosodium glutamate and associated dna repair cell machinery: a literature review”. Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal, vol. 5, no. 8, 2021, p. 1-7. https:doi.org/10.26685/urncst.279
2. , , Roles of Moringa oleifera Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats, Oxidative Medicine and Cellular Longevity, 2018, 4501097, 11 pages, 2018. https:doi.org/10.1155/2018/4501097
3. Farombi EO, Onyema OO. Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin. Human & Experimental Toxicology. 2006;25(5):251-259. https:doi:10.1191/0960327106ht621oa
4. Hazzaa, S. M., Abdelaziz, S. A. M., Abd Eldaim, M. A., Abdel-Daim, M. M., & Elgarawany, G. E. (2020). Neuroprotective Potential of Allium sativum against Monosodium Glutamate-Induced Excitotoxicity: Impact on Short-Term Memory, Gliosis, and Oxidative Stress. Nutrients, 12(4), 1028. https:doi.org/10.3390/nu12041028
5. Shimaa E. Rashad; F. M. Abdel-Tawab; Eman M. Fahmy; A. Attallah; Ekram Ahmed; A. A. Haggran. “ASSESSMENT OF GENOTОXIC EFFECTS OF SOME FOOD ADDITIVES ON SOME HUMAN CANCER CELLS”, Arab Universities Journal of Agricultural Sciences, 27, 1, 2019, 585-593. https:doi: 10.21608/ajs.2019.43668
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The information provided in this document is intended for educational and informational purposes only and should not be construed as medical advice, diagnosis, or treatment. It is essential to consult a qualified healthcare professional for any medical concerns or conditions. The content herein does not substitute for professional medical advice, and individuals should not disregard or delay seeking medical advice based on the information provided.
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